بررسی اثرات ناهنجاری زایی استامینوفن در جنین موش سوری

&nbsp;&nbsp;&nbsp; &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Acetaminophen is a&nbsp; widely used&nbsp; analegesis and antipyretic which is &nbsp;&nbsp; considered&nbsp; safe&nbsp; at&nbsp; therapeutic&nbsp; levels . This&nbsp; medicine is&nbsp; also&nbsp; a&nbsp; kind&nbsp; of &nbsp;&nbsp; influensive substiution via the gut, it is metabolized in liver and&nbsp; converted &nbsp;&nbsp; to consistant&nbsp; and&nbsp; potential&nbsp; toxic&nbsp; metabolits . Acetaminophen&nbsp; and&nbsp; it&rsquo;s &nbsp;&nbsp; metabolits&nbsp; undifficulty passes from decidua and achieves&nbsp; emberyo and &nbsp;&nbsp; is the cause of malformations in emberyo. &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; In this investigation &nbsp;&nbsp;we&nbsp; &nbsp;basically&nbsp; &nbsp;found&nbsp; &nbsp;that &nbsp;&nbsp;the &nbsp;consumption&nbsp; of &nbsp;&nbsp; therapeutic &nbsp;&nbsp;does &nbsp;of &nbsp;acetaminophen&nbsp; ( 48.5&nbsp; mg/kg )&nbsp; in &nbsp;&nbsp;mice ,&nbsp; during &nbsp;&nbsp; sensitive &nbsp;organogenesis &nbsp;days &nbsp;&nbsp;( 7,8,9 &nbsp;and &nbsp;9,10,11 &nbsp;pregnancy ) &nbsp;caused &nbsp;&nbsp; abnormalities&nbsp; that&nbsp; the&nbsp; most &nbsp;important&nbsp; of&nbsp; them&nbsp; included :decrease of &nbsp;&nbsp; weight &nbsp;&nbsp;of &nbsp;emberyo&rsquo;s &nbsp;&nbsp;body &nbsp;in &nbsp;comparison &nbsp;with control group(P<0.05). &nbsp;&nbsp; Another &nbsp;&nbsp;abnormalities &nbsp;&nbsp;observed &nbsp;&nbsp;&nbsp;in&nbsp; &nbsp;&nbsp;this&nbsp; &nbsp;&nbsp;study &nbsp;: &nbsp;decrease &nbsp;of &nbsp;&nbsp;&nbsp;CR , &nbsp;&nbsp; exencephally , &nbsp;&nbsp;absorption &nbsp;&nbsp;of &nbsp;embryo &nbsp;and &nbsp;skeletal&nbsp; system&nbsp; defect.&nbsp; In &nbsp;&nbsp; resumption of&nbsp; research, we also treared&nbsp; the double &nbsp;of&nbsp; the&nbsp; therapeutic &nbsp;&nbsp; dose (97&nbsp; mg/kg)&nbsp; in&nbsp; sensitive&nbsp; organogenesis period&nbsp; to&nbsp; pregnant mouse &nbsp;&nbsp; via the animal feeding , it caused &nbsp;increasing &nbsp;of the&nbsp; abnormalities .&nbsp; As it &nbsp;&nbsp; shows&nbsp; that&nbsp; there&nbsp; is&nbsp; significant decrease in weight and CR in comparison &nbsp;&nbsp; with control group.